RT Article A1 Pfeiffer S T1 Investigation of the relationship between sleep disorders, infection-related gastrointestinal diseases and organ dysfunction T2 Observational Study ED Normamed. Publications for Cause Medicine YR 2023 RD 7/8/2023  UL https://doi.org/10.61029/normamed.2023.01.en AB The recommendation of the Robert Koch Institute in 2004 to conduct studies on the pathogenetic significance of intestinal Candida colonisation for sleep disorders has remained widely unheeded in medical research. The present study therefore follows the recommended approach and investigates the possible role of infections (especially Candida spec.) and mixed infections (especially Candida spec. and Helicobacter pylori) as well as organ dysfunctions possibly caused by them in connection with sleep disorders. 166 patients with chronic sleep disorders were examined on the basis of a comprehensive medical history and combined diagnostics (serology, microbiology, ECG, ultrasound of the kidneys, spleen, liver, gall bladder, pancreas, gastrointestinal, thyroid, vessels, prostate, Douglas space, ovaries, uterus, lymph nodes). Digestive disorders were found in 92 percent of the patients and organ dysfunctions in 70 percent (kidneys, spleen, liver, gall bladder and heart were observed in particular), infections and mixed infections in 79 percent. The results show that sleep disorders often occur with infections and organ dysfunctions. Thus, if the treatment of infections leads to an improvement in sleep, antimicrobial therapy of neglected or unrecognised infections and the potential organ dysfunctions associ